22 days in Spain & Italy Itinerary

22 days in Spain & Italy Itinerary

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Route & dates

22 days in Spain & Italy Itinerary

Start: Rio de Janeiro, Brazil
Fly:  14​h 30​min
1
Madrid, Spain
— 4 nights
Train:  2​h 45​min
2
Seville, Spain
— 1 night
Fly:  3​h 30​min
3
Barcelona, Spain
— 4 nights
Fly:  4​h 45​min
4
Venice, Italy
— 4 nights
Train:  2​h 15​min
5
Florence, Italy
— 3 nights
Train:  1​h 45​min
6
Rome, Italy
— 5 nights
Fly:  15​h 45​min
End: Rio de Janeiro, Brazil


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4
nights
Madrid, Spain

Madrid ©
Madrid is known for its cultural and artistic heritage, lively nightlife, and a dynamic culinary scene.
Give yourself a bit of retail therapy at Mercado San Miguel and El Brabantino. Museum-lovers will appreciate Museo Nacional del Prado and Royal Palace of Madrid. There's much more to do: do a tasting at The Madrid Wine Experience, explore the world behind art at Museo Nacional Centro de Arte Reina Sofía, contemplate the long history of Casa de Campo, and see the interesting displays at Thyssen-Bornemisza Museum.

To see where to stay and tourist information, refer to the Madrid trip builder.

Rio de Janeiro, Brazil to Madrid is an approximately 14.5-hour flight. The time zone difference moving from Brasilia Time to Central European Time is 4 hours. Prepare for a bit cooler weather when traveling from Rio de Janeiro in May: high temperatures in Madrid hover around 26°C and lows are around 13°C. Finish your sightseeing early on the 5th (Fri) so you can take a train to Seville.

Things to do in Madrid

Museums Historic Sites Tours
Find places to stay May 1 — 5:
Highlights from your plan
Prado National Museum ©
Prado National Museum
Royal Palace of Madrid ©
Royal Palace of Madrid
Museo Nacional Thyssen-Bornemisza ©
Museo Nacional Thyssen-Bornemisza

1
night
Seville, Spain

Seville ©
A city of rich Moorish heritage, Seville is the cultural and financial center of southern Spain, and the site of numerous festivals throughout the year.
Start off your visit on the 5th (Fri): explore the world behind art at Seville Museum of Fine Arts, then take in the spiritual surroundings of Seville Cathedral (Catedral de Sevilla), and then get to know the fascinating history of Barrio Santa Cruz. Get ready for a full day of sightseeing on the next day: steep yourself in history at Plaza de Espana and then explore the historical opulence of Royal Alcázar of Seville.

To see other places to visit, reviews, traveler tips, and tourist information, read our Seville vacation builder.

Traveling by train from Madrid to Seville takes 3 hours. Alternatively, you can fly; or drive. Traveling from Madrid in May, things will get a bit warmer in Seville: highs are around 34°C and lows about 17°C. Wrap up your sightseeing by early afternoon on the 6th (Sat) to allow time for travel to Barcelona.

Things to do in Seville

Historic Sites Neighborhoods Museums
Find places to stay May 5 — 6:
Highlights from your plan
Royal Alcázar of Seville ©
Royal Alcázar of Seville
Plaza de España ©
Plaza de España
Barrio Santa Cruz ©
Barrio Santa Cruz

4
nights
Barcelona, Spain

Barcelona ©
Barcelona, the country’s second-largest city, is a cosmopolitan urban center known for its throbbing youthful energy and stellar architecture.
You'll explore the less-touristy side of things at Passeig de Gracia and CELLARER. Your inner history buff will appreciate El Barri Gòtic and Barcelona Cathedral. And it doesn't end there: admire the striking features of La Sagrada Familia, browse the exhibits of Casa Batlló, take a stroll through Las Ramblas, and pause for some photo ops at Casa Milà.

For reviews, other places to visit, traveler tips, and more tourist information, you can read our Barcelona online itinerary creator.

You can fly from Seville to Barcelona in 3.5 hours. Other options are to take a train; or drive. When traveling from Seville in May, plan for slightly colder days and about the same nights in Barcelona: temperatures range from 25°C by day to 17°C at night. Finish your sightseeing early on the 10th (Wed) so you can travel to Venice.

Things to do in Barcelona

Historic Sites Neighborhoods Shopping
Find places to stay May 6 — 10:
Highlights from your plan
Passeig de Gracia ©
Passeig de Gracia
Basilica of the Sagrada Familia ©
Basilica of the Sagrada Familia
El Barri Gòtic ©
El Barri Gòtic

4
nights
Venice, Italy

Venice ©
Virtually unchanged for the last six centuries, Venice is actually a group of islands made famous by a series of canals, bridges, monuments, piazzas, and narrow pedestrian lanes.
Shop till you drop at Isola di Burano and I Tre Mercanti. Deepen your sense of the past at sights like Peggy Guggenheim Collection and St Mark's Campanile. The adventure continues: admire the striking features of Doges' Palace, make a trip to Basilica di San Marco, contemplate the waterfront views at Canal Grande, and get to know the fascinating history of St. Mark's Square.

To see traveler tips, other places to visit, ratings, and tourist information, read our Venice travel itinerary planner.

Traveling by flight from Barcelona to Venice takes 5 hours. Alternatively, you can drive; or take a train. In May, daily temperatures in Venice can reach 25°C, while at night they dip to 15°C. Finish your sightseeing early on the 14th (Sun) so you can take a train to Florence.

Things to do in Venice

Museums Historic Sites Parks
Find places to stay May 10 — 14:
Highlights from your plan
Canal Grande ©
Canal Grande
Doge's Palace ©
Doge's Palace
Piazza San Marco ©
Piazza San Marco

3
nights
Florence, Italy

Florence ©
Considered a cultural, artistic, and architectural jewel of Italy, Florence is the birthplace of the Italian Renaissance.
Eschew the tourist crowds and head to Piazza del Campo and Piazza della Signoria. Visit Siena Cathedral and Museo Nazionale del Bargello for their historical value. When in Florence, make a side trip to see Bianco e Nero di Staccioli Sonia in Siena, approximately 1:25 hours away. Next up on the itinerary: see the interesting displays at Uffizi Gallery, take in the spiritual surroundings of Cathedral of Santa Maria del Fiore, snap pictures at Ponte Vecchio, and appreciate the extensive heritage of Piazza del Duomo.

To see other places to visit, maps, ratings, and tourist information, refer to the Florence trip generator.

Getting from Venice to Florence by train takes about 2.5 hours. Other options: drive; or fly. Expect a daytime high around 28°C in May, and nighttime lows around 13°C. Finish your sightseeing early on the 17th (Wed) to allow enough time to take a train to Rome.

Things to do in Florence

Museums Historic Sites Tours

Side Trip

Siena
Find places to stay May 14 — 17:
Highlights from your plan
Piazza del Duomo ©
Piazza del Duomo
Duomo di Siena ©
Duomo di Siena
Gallerie Degli Uffizi ©
Gallerie Degli Uffizi

5
nights
Rome, Italy

Rome ©
Aptly nicknamed the Eternal City, Rome is the birthplace of the Roman Empire, one of the world's greatest civilizations ever.
Give yourself a bit of retail therapy at Via Condotti and Porta Portese. Step off the beaten path and head to Palatine Hill and St. Clement Basilica. You'll find plenty of places to visit near Rome: Tivoli (Villa Adriana & Villa d'Este). There's still lots to do: see the interesting displays at St. Peter's Basilica, contemplate the long history of Roman Forum, contemplate in the serene atmosphere at Church of St. Louis of the French, and ponder the design of Trevi Fountain.

For where to stay, maps, traveler tips, and tourist information, refer to the Rome online itinerary creator.

Traveling by train from Florence to Rome takes 2 hours. Alternatively, you can drive; or fly. In May, daytime highs in Rome are 28°C, while nighttime lows are 15°C. Wrap up your sightseeing by early afternoon on the 22nd (Mon) to allow enough time to travel back home.

Things to do in Rome

Historic Sites Museums Shopping

Side Trips

Tivoli, Vatican City
Find places to stay May 17 — 22:
Highlights from your plan
Colosseum ©
Colosseum
Pantheon ©
Pantheon
Roman Forum ©
Roman Forum

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